Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	70	0.0	0.723	0.079	0.159
biological_process	el	70	0.011	0.966	0.618	0.247
biological_process	ka	70	0.0	0.698	0.075	0.159
biological_process	rf	70	0.0	0.723	0.079	0.159
cellular_component	ct	4	0.0	0.109	0.032	0.045
cellular_component	el	4	0.0	0.738	0.329	0.332
cellular_component	ka	4	0.002	0.145	0.043	0.059
cellular_component	rf	4	0.0	0.109	0.031	0.045
disease	ct	24	0.001	0.863	0.129	0.235
disease	el	24	0.005	0.806	0.196	0.245
disease	ka	24	0.0	0.942	0.137	0.258
disease	rf	24	0.001	0.863	0.129	0.236
genetic_interaction_unweighted	ct	60	0.0	0.991	0.417	0.324
genetic_interaction_unweighted	el	60	0.0	0.984	0.432	0.321
genetic_interaction_unweighted	ka	60	0.002	1.0	0.934	0.249
genetic_interaction_unweighted	rf	60	0.0	0.99	0.42	0.324
genetic_interaction_weighted	ct	60	0.0	0.991	0.415	0.324
genetic_interaction_weighted	el	60	0.0	0.982	0.429	0.321
genetic_interaction_weighted	ka	60	0.0	1.0	0.933	0.249
genetic_interaction_weighted	rf	60	0.0	0.99	0.422	0.325
molecular_function	ct	7	0.0	0.75	0.162	0.274
molecular_function	el	7	0.01	0.755	0.491	0.215
molecular_function	ka	7	0.0	0.777	0.156	0.275
molecular_function	rf	7	0.0	0.75	0.162	0.274
pathway	ct	30	0.001	0.996	0.073	0.181
pathway	el	30	0.001	0.207	0.03	0.053
pathway	ka	30	0.001	1.0	0.308	0.454
pathway	rf	30	0.001	0.176	0.033	0.049
phenotype	ct	23	0.0	0.848	0.196	0.274
phenotype	el	23	0.033	0.837	0.439	0.189
phenotype	ka	23	0.0	0.965	0.225	0.305
phenotype	rf	23	0.0	0.876	0.197	0.277
protein_interaction_unweighted	ct	73	0.0	0.741	0.038	0.125
protein_interaction_unweighted	el	73	0.0	0.779	0.039	0.132
protein_interaction_unweighted	ka	73	0.001	1.0	0.347	0.471
protein_interaction_unweighted	rf	73	0.0	0.74	0.037	0.124
protein_interaction_weighted	ct	73	0.0	0.749	0.038	0.126
protein_interaction_weighted	el	73	0.001	0.885	0.47	0.244
protein_interaction_weighted	ka	73	0.0	1.0	0.344	0.473
protein_interaction_weighted	rf	73	0.0	0.735	0.038	0.124

Table 2. Backup position values for every kernel after integration

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels