Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.723 0.079 0.159
biological_process el 70 0.011 0.966 0.618 0.247
biological_process ka 70 0.0 0.698 0.075 0.159
biological_process rf 70 0.0 0.723 0.079 0.159
cellular_component ct 4 0.0 0.109 0.032 0.045
cellular_component el 4 0.0 0.738 0.329 0.332
cellular_component ka 4 0.002 0.145 0.043 0.059
cellular_component rf 4 0.0 0.109 0.031 0.045
disease ct 24 0.001 0.863 0.129 0.235
disease el 24 0.005 0.806 0.196 0.245
disease ka 24 0.0 0.942 0.137 0.258
disease rf 24 0.001 0.863 0.129 0.236
genetic_interaction_unweighted ct 60 0.0 0.991 0.417 0.324
genetic_interaction_unweighted el 60 0.0 0.984 0.432 0.321
genetic_interaction_unweighted ka 60 0.002 1.0 0.934 0.249
genetic_interaction_unweighted rf 60 0.0 0.99 0.42 0.324
genetic_interaction_weighted ct 60 0.0 0.991 0.415 0.324
genetic_interaction_weighted el 60 0.0 0.982 0.429 0.321
genetic_interaction_weighted ka 60 0.0 1.0 0.933 0.249
genetic_interaction_weighted rf 60 0.0 0.99 0.422 0.325
molecular_function ct 7 0.0 0.75 0.162 0.274
molecular_function el 7 0.01 0.755 0.491 0.215
molecular_function ka 7 0.0 0.777 0.156 0.275
molecular_function rf 7 0.0 0.75 0.162 0.274
pathway ct 30 0.001 0.996 0.073 0.181
pathway el 30 0.001 0.207 0.03 0.053
pathway ka 30 0.001 1.0 0.308 0.454
pathway rf 30 0.001 0.176 0.033 0.049
phenotype ct 23 0.0 0.848 0.196 0.274
phenotype el 23 0.033 0.837 0.439 0.189
phenotype ka 23 0.0 0.965 0.225 0.305
phenotype rf 23 0.0 0.876 0.197 0.277
protein_interaction_unweighted ct 73 0.0 0.741 0.038 0.125
protein_interaction_unweighted el 73 0.0 0.779 0.039 0.132
protein_interaction_unweighted ka 73 0.001 1.0 0.347 0.471
protein_interaction_unweighted rf 73 0.0 0.74 0.037 0.124
protein_interaction_weighted ct 73 0.0 0.749 0.038 0.126
protein_interaction_weighted el 73 0.001 0.885 0.47 0.244
protein_interaction_weighted ka 73 0.0 1.0 0.344 0.473
protein_interaction_weighted rf 73 0.0 0.735 0.038 0.124

Table 2. Backup position values for every kernel after integration

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels